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Search Results for " hepatocyte growth factor receptor "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T37596	Terevalefim		c-Met/HGFR
	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.		c-Met/HGFR
T6517	Golvatinib	E-7050	VEGFR , c-Met/HGFR
	Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic ...		VEGFR , c-Met/HGFR
T77437	Telisotuzumab	ABT-700,Mab-224G11	c-Met/HGFR
	Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitu...		c-Met/HGFR
T39507	Fosgonimeton	ATH-1017
	Fosgonimeton is a hepatocyte growth factor receptor agonist (WO2017210489).
T71636	Golvatinib tartrate
	Golvatinib tartrate is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic ...
T1661L	Crizotinib acetate	PF02341066,PF-2341066,PF 02341066,PF-02341066,PF2341066
	Crizotinib, an orally bioavailable agent, belongs to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity.
T13108L	Pamufetinib mesylate	TAS-115 mesylate,TAS-115 methanesulfonate	Others
	TAS-115 mesylate is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively).		Others
T71187	Foretinib phosphate
	Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vas...
T70434	Vabametkib
	Vabametkib, a potent hepatocyte growth factor receptor (HGFR) inhibitor, exhibits anti-proliferative effects on Hs746T cells and selectively inhibits c-Met with an IC50 value of 7 nM, showcasing its potential as an antin...
T80884	Val-Cit-amide-Ph-Maytansine
	Val-Cit-PAB-MMAE is a molecular entity designed to function as an antibody-drug conjugate (ADC) or as a component of bispecific antigen-binding molecules, specifically targeting the hepatocyte growth factor receptor know...
T76745	Ficlatuzumab
	Ficlatuzumab, a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF), impedes the HGF/c-Met signaling pathway. By blocking this pathway, it prevents c-Met receptor-mediated cancer cell proliferation,...
T75940	Norleual TFA
	Norleual TFA, an analog of angiotensin (Ang) IV, functions as a hepatocyte growth factor (HGF)/c-Met inhibitor, displaying a potent inhibition capability with an IC50 of 3 pM. Additionally, it acts as an AT4 receptor ant...
T80885	Val-Cit-amide-Cbz-N(Me)-Maytansine
	Val-Cit-amide-Cbz-N(Me)-Maytansine is a molecule that functions both as an antibody and a bispecific antigen-binding entity, targeting the hepatocyte growth factor receptor c-Met (MET), and is used in the formulation of ...
T28240	Ono 1301	Ono-1301,Ono1301
	Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only wit...

Compounds

Target: VEGFR, c-Met/HGFR

Telisotuzumab

T77437

Synonym: ABT-700,Mab-224G11

Synonym: PF02341066,PF-2341066,PF 02341066,PF-02341066,PF2341066

Target:

Pamufetinib mesylate

T13108L

Synonym: TAS-115 mesylate,TAS-115 methanesulfonate

Val-Cit-amide-Ph-Maytansine

Val-Cit-amide-Cbz-N(Me)-Maytansine

Synonym: Ono-1301,Ono1301

Target:

Cat No.	Product Name	Synonyms	Targets
T13108	Pamufetinib	H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115	VEGFR , c-Met/HGFR
	Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively).		VEGFR , c-Met/HGFR

Natural Products

Pamufetinib

T13108

Synonym: H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115

Target: VEGFR, c-Met/HGFR

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which un...
TMPJ-00059	IL-7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions...
TMPK-01155	MANSC1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	MANSC1 contains 1 MANSC domain. MANSC is a seven-cysteine-containing domain present in animal membrane and extracellular proteins. MANSC (motif at N terminus with seven cysteines) is a novel domain with a well-conserved ...
TMPH-03312	HGF Protein, Rat, Recombinant (GST)	Rat	E. coli
	Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase M...
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain ...
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain ...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...